Scientific Program - Final

 

 

 

Program of the 3rd International Conference of the EMR-IBS

.: Sunday .:. Monday .:.  Tuesday .:. Wednesday .:. Thursday :.

Sunday, May 8, 2005

Time

8:00 am - 5:00 pm

Workshop on Clinical Trials

 

Monday, May 9, 2005

Time

 

Preconference Course

2:00 - 6:00 pm

Statistical Analysis of Microarray Data,
David Stephens; Dept of Mathematics, Imperial College of London, UK

Time

8:30 pm - 10:00 pm

Opening Mixer and Pre-Registration (Corfu Imperial Hotel)

 

Tuesday, May 10, 2005

Time

8:30 am - 9:00 am

Registration

9:00 am - 10:00 am

Opening Session
Welcoming Remarks and Keynote Address

Chair: Urania Dafni; University of Athens, Greece

9:00 am - 9:15 am


Welcoming Remarks by the EMR-IBS President

Refik Burgut; Cukurova University, Adana, Turkey

 

9:15 am - 10:00 am

 

Keynote Address

Biostatisticians, Biostatistical Science and the Future,
Marvin Zelen
; Harvard School of Public Health,
USA

 

10:00 am - 11:30 am

(1:30)

Session A
Analysis of Microarray Experiments

Chair: Maria-Grazia Valsecchi; University of Milano-Bicocca, Italy

10:00 am - 10:30 am

Pooling Data Across Microarray Experiments Using Different Versions of Affymetrix Oligonucleotide Arrays,

Jeffrey Morris, Zhang L, Wu C, Baggerly K, Coombes K; University of Texas M.D. Anderson Cancer Center, USA

10:30 am – 10:50 am

Combining Multiple Microarray Studies under Various Conditions,

Park T, Yi S, Choi H, Lee S-Y; Seoul National University, Korea

10:50 am – 11:10 am

Identifying Periodically Expressed Transcripts in Microarray Time Series Data,

Fokianos K; University of Cyprus, Cyprus

11:10 am – 11:30 am

Epigenetic Hypothesis Tests for Methylation and Acetylation
in a Triple Microarray System,

Li L, Shi H, Yiannoutsos CT, Huang T M-H, Nephew KP; Indiana University, USA

11:30 am - 11:50 am

Coffee Break

 

11:50 am - 1:40 pm

(1:50)

Parallel Sessions

Session B1
Modelling of Longitudinal Data

Session B2
Statistical
Methodology I

 

Session B1
Modelling of Longitudinal Data

Chair: Constantine Gatsonis; Brown University, USA

11:50 am - 12:20 pm

Modelling, Estimation and Diagnostics for Longitudinal Binary Data with Dropout,

Robin Henderson & Rosemire Fiaccone; Lancaster University, Newcastle University, UK

12:20 pm - 12:40 pm

Marginalized Multilevel Models for Multivariate Longitudinal Binary Data,

Ilk O; Middle East Technical University, Turkey

12:40 pm - 1:00 pm

Estimating Future Age Specific Breast cancer Mortality Using a Novel Approach in Demographic Forecasting,
Bircan E, Hyndman R, Gertig D; University of Melbourne, Monash University, Australia

1:00 pm - 1:20 pm

Modelling Bivariate Longitudinal Data in the Presence of Informative Drop-outs: Robustness of a Joint Parametric Model,

Pantazis N & Touloumi G; University of Athens, Greece

1:20 pm - 1:40 pm

Primary and Sensitivity Analysis of Incomplete Longitudinal Clinical Trial Data,

Beunckens C, Molenberghs G, Jansen I, Verbeke G, Kenward MG; Limburgs Universitair Centrum, Belgium

 

11:50 am - 1:40 pm

(1:50)

Session B2
Statistical Methodology I

Chair: Laurence Freedman; Bar Ilan University, Israel

11:50 am - 12:10 pm

Limiting the Risk of Data Disclosure through Variance Replicate Weights in the National Health and Nutrition Examination Surveys,
Lu Wen; Simon Fraser University, Canada

12:10 pm - 12:30 pm

A Discrepancy Based Robust Model Selection Criterion,
Mattheou K & Karagrigoriou A; University of Cyprus, Cyprus

12:30 pm - 12:50 pm

Modelling Bivariate Count Data Using Copula functions,
Nikoloulopoulos AK & Karlis D; Athens University of Economics and Business, Greece

12:50 pm - 1:10 pm

An Approach to the Analysis of Multivariate Ordinal Repeated Mmeasures Data,
Vasdekis V & Dellaportas P; Athens University of Economics and Business, Greece

1:10 pm - 1:30 pm

Analysis of Noninferiority Trials in Small Sample Matched Pair Designs with a Structural Zero,
Okasha MK; Al-Azhar University, Gaza, The Palestinian Authority

1:30 pm - 1:40 pm

Discussion

1:40 pm - 2:40 pm

Lunch break

 

 2:40 pm - 4:50 pm

 (2:10)

Parallel sessions

Session C1
Clinical Trials I

Session C2
Statistical Methods in Agricultural Research

 

Session C1
Clinical Trials I

Chair: Stephen Lagakos; Harvard University, USA

 

2:40 pm - 3:10 pm

 

Statistical Challenges in Medical Device Clinical Trials,

Sharon-Lise T. Normand & O’Malley AJ; Harvard School of Public Health, USA

3:10 pm - 3:30 pm

Validation of Surrogate Markers in Multiple Randomized Clinical Trials with Repeated Measurements: Canonical Correlation Approach,

Alonso A, Geys H, Molenberghs G, Kenward G, Vangeneugden T; Limburgs Universitair Centrum, Belgium

3:30 pm - 3:50 pm

Diagnostic tests for Gamma and Inverse Gaussian Distributions of Frailty,

Economou P &  Caroni C; National Technical University of Athens, Greece

3:50 pm - 4:10 pm

Overdispersion Modelling with Individual Random Effects and Penalized Likelihood,

Perperoglou A & Eilers PHC; Leiden University Medical Center, The Netherlands

4:10 pm - 4:30 pm

Interval Censoring and Truncation: Statistical Inference with Applications,

Huber-Carol C & Vonta F; University of Cyprus, Cyprus

4:30 pm - 4:50 pm

Discussion

 

2:40 pm - 4:50 pm

(2:10)

Session C2
Statistical Methods in Agricultural Research

Chair: Stergios Tzortzios; University of Thessaly, Greece

2:40 pm - 3:10 pm

Bayesian solutions to some decision problems in agriculture,

Chris Theobald; Biomathematics & Statistics, Scotland and University of Edinburgh, UK

3:10 pm - 3:30 pm

Bayesian Re-Analysis of a Quantitative Trait Locus in Broilers Accounting for Multiple Environments by Scaling,

van Kaam JBCHM, Bink MCAM, van Arendonk JAM, Quaas RL;

Istituto Zooprofilattico Sperimentale della Sicilia "A. Mirri”, Italy and Wageningen University, The Netherlands and Cornell University, USA

3:30 pm - 3:50 pm

Incorporating Risk in Ranking Dairy Sires,

Shadparvar AA; Guilan University, Iran

3:50 pm - 4:10 pm

Some New Biometrical Approaches on an Optimum Groups Selection in Biological Applications,

Tzortzios S & Ganatsiou Ch; University of Thessaly, Greece

4:10 pm - 4:30 pm

Systematic Sampling in 2-Dimensional Populations: Discrete Variables with a Linear Trend,

Farmakis N; Aristotle University of Thessaloniki, Greece

4:30 pm - 4:50 pm

A Comparative Study of Permutation Tests in a Factorial Design,

Önder H, Çankaya S, Tahtali Y, Cebeci Z; Çukurova University, Turkey

4:50 pm - 5:10 pm

Coffee break

5:10 pm - 6:10 pm

Business Meeting

6:10 pm - 7:30 pm

Break

7:30 pm - 9:30 pm

Poster Presentation and Reception

 

Wednesday, May 11, 2005

Time

9:00 am - 11:10 am

(2:10)

Parallel sessions

Session D1
Recent Developments in ROC Methodology Relating to the Diagnosis and Prediction of Disease

Session D2

Statistics, Cancer and the Mediterranean Diet

 

 

Session D1
Recent Developments in ROC Methodology Relating to the Diagnosis and Prediction of Disease

Chair: David Faraggi; University of Haifa, Israel

 

9:00 am - 9:30 am

 

Recent Developments in the Use of ROC Curves to Evaluate Diagnostic Systems,

Howard E. Rockette; University of Pittsburgh, USA

9:30 am – 10:00 am

ROC Analysis for Screening Tests,
Constantine Gatsonis
& Hsiu M; Brown University & University of California, San Francisco, USA

10:00 am – 10:20 am

ROC Analysis for Markers with Mass at Zero,

Schisterman EF, Reiser B, Faraggi D; University of Haifa, Israel

10:20 am – 10:40 am

Information Theory and Kullback-Leibler Distance Approach in the Evaluation of Diagnostic Test Performance,

Arslan U, Bozkurt B., Irkec M., Karaagaoglu E; Hacettepe University, Turkey

10:40 am – 11:00 am

Estimation of the ROC Curve under Verification Bias,

Fluss R, Faraggi D, Reiser B, Rotnitzky A; University of Haifa, Israel & Harvard School of Public Health, USA

11:00 am – 11:10 am

Discussion

 

9:00 am - 11:10 am

(2:10)

Session D2

Statistics, Cancer and the Mediterranean Diet

Chair: Guadalupe Gomez; Universitat Politecnica de Catalunya, Spain

9:00 am - 9:30 am

Healthy Diet in Relation to Childhood Diseases and Conditions,

Eleni Petridou & Ntouvelis E; University of Athens, Greece

9:30 am - 9:50 am

Population Distributions of Usual Intake Adjusted for Dietary Misreporting,

Freedman LS, Yanetz R, Kipnis V, Midthune D, Dodd K, Krebs-Smith S, Subar A; Bar Ilan University, Israel and US National Cancer Institute, USA

9:50 am – 10:10 am

Extending the Gail Model for Breast Cancer Risk Prediction to Account for Dietary Modifiable Factors in the Italian Population,

Calza S, Ferraroni M, Decarli A; University of Brescia, Italy

10:10 am – 10:30 am

Does the Significance Level of Treatments Have an Effect on Judgment in Surrogate Endpoint Validation: An Application to Colon Cancer Data,
Sertdermir Y, Burgut R, Unal I; School of Medicine, Cukurova University, Adana, Turkey

10:30 am – 10:50 am

Cancer Problem in Turkey: Present and Future,
Tuncer I & Burgut R; School of Medicine, Cukurova University, Adana, Turkey

10:50 am – 11:10 am

The Association between Hepatitis C Virus and Non-Hodgkin's Lymphoma in Southern Turkey and Review of Other Regions,
Paydas S; School of Medicine, Cukurova University, Adana, Turkey

11:10 am - 11:30 am

Coffee break

 

11:30 am - 1:30 pm

(2:00)

Parallel sessions

Session E1
Statistical Modelling in Epidemiology

Session E2
Statistical Methodology II

 

Session E1
Statistical Modelling in Epidemiology

Chair: Refik Burgut; Cukurova University, Adana, Turkey

11:30 am - 12:00 pm

Cluster Mapping via Tomographic Methods,
Forsberg L, Jeffery C, Ozonoff A, Marcello Pagano;
Harvard School of Public Health, USA

12:00 pm - 12:30 pm

 

With Whom Do we Mix? Mixing Patterns in Age Structured Population, An Investigation of a Possible Configuration of the WAIFW Matrix,

Ziv Shkedy, Aerts M, Molenberghs G,  Beutels P, Van Damme P, Van-Effelterre T; Limburgs Universitair Centrum, Belgium

12:30 pm - 12:50 pm

Use of the Cox Model for the Analysis of Avian Influenza Epidemics,

Rossi E, Galimberti S, Valsecchi M; University of Milano-Bicocca, Milano and Istituto Zooprofilattico Sperimentale delle Venezie, Legnaro, Italy

12:50 pm - 1:10 pm

A Mathematical Model to Describe Viral Dynamics during Pegylated Interferon Alpha-2b Therapy in Patients with Chronic Hepatitis B,

Sypsa V & Hatzakis A; University of Athens, Greece

1:10 pm - 1:30 pm

Assessing Co-morbidity of Binary Traits: Applications to Population-based Registry,
Shoukri M & Donner A; King Faisal Specialist Hospital, Saudi Arabia & University of Western Ontario, Canada

 

11:30 am - 1:30 pm

(2:00)

Session E2
Statistical Methodology II

Chair: Ilia Vonta; University of Cyprus, Cyprus

11:30 am - 11:50 am

Comparing the Survival of Two Groups for the Early Detection of Screening Trials,

Ping Hu; National Cancer Institute, USA

11:50 am - 12:10 pm

Optimal Cross-Over Two Treatment Designs,

Kounias S & Chalikias M; University of Athens, Greece

12:10 pm - 12:30 pm

Adaptive Selection and Multiple Testing of Efficient and Safe Doses,

Koenig F; Werner Brannath and Peter Bauer, University of Vienna, Austria

12:30 pm - 12:50 pm

Impact of Misspecified Random-Effects Distribution on Maximum Likelihood Estimation in Generalized Linear Mixed Models,

Litière S, Alonso A, Molenberghs G; Limburgs Universitair Centrum, Belgium & Universitair Campus, Diepenbeek, Belgium

12:50 pm - 1:10 pm

Meta-Analysis Of Safety Data Of Coxibs in Comparison with Non Selective NSAIDS - Methodological Issues,

Yiannakopoulou E, Papadopoulos JS, Bamia Ch, Damianou Ch; University of Athens, Greece

1:10 pm - 1:30 pm

Mediation Analyses with Structural Mean Models,

Tenhave T; University of Pennsylvania, USA

1:30 pm - 2:30 pm

Lunch break

2:30 pm - 3:50 pm

Panel Discussion
Statistical Impact of International Biopharmaceutical Guidelines,
Allan Sampson, Emmanuel Lesaffre, Willi Maurer, Armin Koch; University of Pittsburgh, USA & Katholieke Universitaet Leuven, Belgium & Novartis & Bundesinstitut f. Arzneimittel und Medizinprodukte, Germany

3:50 pm - 4:10 pm

Coffee break

 

4:10 pm - 5:50 pm

(1:40)

Parallel sessions

Session F1
Multiple Comparisons in Biostatistics

Session F2

Modelling of Survival Data

 

Session F1
Multiple Comparisons in Biostatistics

Chair: Mohamed Shoukri; King Faisal Specialist Hospital, Saudi Arabia

 4:10 pm - 4:40 pm

False Discovery Rate Adjusted Multiple Confidence Intervals for Selected Parameters,
Yoav Benjamini
, Yekutieli D;
Tel-Aviv University, Israel

 4:40 pm - 5:10 pm

Genomic Screening in Family Based Association Testing and the Multiple Testing Problem,

Van Steen K, McQueen MB, Herbert A, Raby B, Lyon H, Murphy A, Su J, Datta S, Rosenow C, Silverman EK, Laird NM, Weiss ST,  Lange C; Harvard School of
Public Health, Boston University and AFFYMETRIX, INC., USA

 5:10 pm - 5:40 pm

Complexity of Data and Analysis Related to FDR Control in Microarray Experiments,
Reiner A, Yekutieli D, Benjamini Y; Tel-Aviv University, Israel

 5:40 pm - 5:50 pm

Discussion

 

4:10 pm - 5:50 pm

(1:40)

Session F2
Modelling of Survival Data

Chair: Takis Papaioannou; University of Pireaus, Greece

4:10 pm - 4:30 pm

A Pseudo Partial Likelihood Method for Semi-Parametric Survival Regression,

Zucker D; Hebrew University, Israel

4:30 pm - 4:50 pm

Noninformative and Constant-sum Conditions for Interval-Censored Survival Data,

Calle ML, Oller R, Gomez G; Universitat de Vic & Universitat Politecnica de Catalunya, Spain

4:50 pm - 5:10 pm

Bayesian Factor Analysis for Modelling Spatial and Temporal Variation in Cancer Mortality in Greece,

Tzala E & Best N; Imperial College London, UK

5:10 pm - 5:30 pm

Prospective Survival Analysis with a General Semiparametric Shared Frailty

Model - A Pseudo Full Likelihood Approach,

Gorfine M; Bar-Ilan University, Israel

5:30 pm - 5:50 pm

Inference for Survival Distributions Based on Interrupted Hazards,

Griffin BA & Lagakos S; Harvard School of Public Health, USA

 

 

5:50 pm - 8:30 pm

Break - New Executive Committee Meeting (5:50 pm-7:00 pm)

8:30 pm

Buses to Corfu town outing

 

Thursday, May 12, 2005

Time

9:00 am - 10:40 am

(1:40)

Session G
Competing Risks in Survival Analysis

Chair: Geert Molenberghs; Limburgs Universitair Centrum, Belgium

9:00 am - 9:30 am

Competing Risks: Modelling Cause Specific Hazard and Crude Cumulative Incidence Functions,

Patrizia Boracchi, Antolini L, Biganzoli E; Istituto Nazionale per lo Studio e la Cura dei Tumori di Milano, Italy

9:30 am - 9:50 am

 

Estimation and Model Selection for the Competing Risks Model with Masked Causes of Failure,

Craiu RV; University of Toronto, Canada

9:50 am - 10:10 am

 

Bounding Marginal Probability of Treatment Failure due to Specific Cause in Competing Risks Setup,

Antolini L, Biganzoli E, Boracchi P; Universita degli Studi di Milano, Italy

10:10 am - 10:30 am

 

A Method for Analyzing Disease-Specific Mortality with Missing Cause of Death Information,
Ruan PK
& Gray RJ; Harvard School of Public Health & Dana-Farber Cancer Institute, USA

10:30 am - 10:40 am

Discussion

10:40 am - 11:00 am

Coffee break

 

 

11:00 am - 1:10 pm

(2:10)

Parallel Sessions

Session H1
Clinical Trials II

Session H2

Measurement Error in Epidemiology and Medicine

 

Session H1
Clinical Trials II

Chair: Marvin Zelen; Harvard School of Public Health, USA

 

11:00 am - 11:30 am

 

Randomization, Permuted Blocks, and Covariates in Clinical Trials,

Lu Zheng; Harvard School of Public Health, USA

11:30 am - 11:50 am

Bioequivalence Studies with Generalized p –values,

Poulopoulou S & Papaioannou T; University of Piraeus, Greece

11:50 am - 12:10 pm

Sensitivity Analysis Tools for Incomplete Data,

Molenberghs G; Limburgs Universitair Centrum, Belgium

12:10 pm - 12:30 pm

Simple Formulas for Confidence Intervals for Quantiles of the Normal and Log-Normal Distributions,

Stephens M; Simon Fraser University, Canada

12:30 pm - 12:50 pm

Weighted Stratified Estimators for the Survival Function in the Presence of Dependent Censoring,

Gomez G, Serrat C, Calle ML; Universitat Politecnica de Catalunya, and Universitat de Vic, Spain

12:50 pm - 1:10 pm

Comparison of Distributions for Ordered Categorical Data with Application to Clinical Trials,

Kateri M; University of Piraeus, Greece

 

 

11:00 am - 1:10 pm

(2:10)

Session H2

Measurement Error in Epidemiology and Medicine

Chair: Mahmoud Okasha; Al-Azhar University, Gaza, The Palestinian Authority

11:00 am - 11:30 pm

Structural and Functional Cox Proportional Hazards Models with Covariate Misclassification,

Donna Spiegelman & Zucker D; Harvard School of Public Health, USA and Hebrew University, Israel

 

11:30 am - 12:00 pm

 

Imputation Methods for Adjusting for Covariate Measurement Error,

Victor Kipnis; National Cancer Institute, USA

12:00 pm - 12:20 pm

A General Method for Dealing with Misclassification in Regression: the Misclassification SIMEX,

Lesaffre E, Kuechenhoff H, Mwalili S; Katholieke Universiteit Leuven, Belgium & Ludwig-Maximilians-Universität, München, Germany

12:20 pm - 12:40 pm

Comparison of Measurement Error Model with Latent Class Model in
Estimating Sensitivity & Specificity of a Screening Test with an Imperfect
Gold Standard,

Wand H, Zhou B, Spiegelman D; Australia & Harvard School of Public Health, USA

12:40 pm - 1:00 pm

A Bayesian Model to Correct for Measurement Error the Diet/Disease

Relationship in a Multi-Centric Study: the Experience of the EPIC Study,

Ferrari P, Carroll R, Riboli E; International Agency for Research on

Cancer, France and Texas A&M University, USA

1:00 pm - 1:10 pm

Discussion

1:10 pm - 1:30 pm

Student Awards
Closing Session

.: Home Page .:. Invited Speakers :.

Last update: April 27, 2005